Couple and family relationships have changed in different aspects in the recent history of Latin America. This paper reviewed comparative studies on couple and family relationships in Latin America published between 2001 and 2015. These studies used data from different countries. The contents analyzed in these investigations were divided in five main themes: (a) family size, structure and diversity; (b) couple and family internal dynamics, including couple and family formation and dissolution, gender and social roles, social care and protection, and couple and family violence; (c) couple, family and health; (d) couple, family and education; and, (e) couple, family and economy. Although comparative studies in Latin America are based mainly on data from national censuses and have a demographic approach, the comparative perspective is proposed as an important mean for the integration of diverse disciplines and the development of international cooperation in studies about couple and family in Latin America. Macro and micro perspectives, as well as quantitative and qualitative data, may complement each other and contribute to a more integrated knowledge about couple and family relationships in the region. Couple and family internal structure and dynamics are related to Latin American society and culture in diverse ways. Some possibilities and suggestions for future investigations are also presented.